The wolf tilts her head. She didn’t get it.
"What about me?"
"You are all so adorable…" Helena mutters, trying to figure it out before huffing. "Nope. You all tie."
"I suppose that makes sense. National security and all," she remarked. Adrianna did her best to hide the disappointment that her girlfriend had managed to gloss over their relationship when conversing with the other woman. "Yeah, we’ve been together a little while. She said she brought me here because I’m her ‘one,’ which I don’t totally get but it sounds like a title I’d like to keep."
"Well I"m glad to hear that Claudia has been doing well for herself. I haven’t heard from her quite some time, actually. It’s good that she’s found someone. Though our conversation was never much about her well being, I can’t help but feel a bit motherly towards her," Helena said, leading the way quickly. "How did the two of you meet?"
Jo nods, nuzzling into Helena. “Yeah…” She sighs happily. “You’re adorable. Really adorable.” She nuzzles into HG some more.
"Audrey, though, is cuter. So sorry."
"Well I understand that one as it is completely true. She is the most adorable. Asides from Myka," Helena says, narrowing her eyes. "And you." You could almost see her trying to decide, but of course it was impossible.
Once the artifact had been neutralized, Pete sealed the bag and packed it along with the rest of his things. He'd visit HG once more, for the promised tour and then head back home. He was now standing in front of the Bering-Wells home; he rapped the door.
Helena opened the door with a smile. “Hello Pete! Come right on in,” she said. She was dressed a bit down from normal, for once wearing a t-shirt instead of a button down. “The babysitter is already with Audrey, I just have to grab a few things first.”
How had she done it? How had H.G. Wells adapted to modern times? The more he looked around, the more he realized she had, in fact, settled. A computer, photos of what seemed to be a normal family life. This was not how you pictured a villain’s hideout, where was the torture chamber, the weapons, the broad comfy chair from which she sat and cackled while petting some evil pet? How long had it taken her to reach this point? Did she finally feel like the times had caught up—his train of thought was halted by Helena’s return.
“Where to, Miss?” he smiled looking back at her. She really had changed… hopefully for the best. “To the stars?”
Titanic… how caught up was she with Pop Culture? He took a rather dramatic bow and the waved his arm, motioning H.G. to go first.
Helena gave Pete a baffled look as if she was trying to recall what exactly he meant. “To infinity and beyond?” she countered, tilting her head. To be completely honest she had no idea what Pete was talking about, but she moved ahead of the man. Then she waited, hoping that she had given a proper response.
Throughout the world, there are many different types of people, and their identity can tell a lot about where they live. The type of job they work, the kind of car they drive, and the foods they eat can all be used to predict the country, the state, or maybe even the city a person lives in.
The brain is no different. There are many types of neurons, defined largely by the patterns of genes they use, and they “live” in numerous distinct brain regions. But researchers do not yet have a comprehensive understanding of these neuronal types and how they are distributed in the brain. Today, a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Partha Mitra describes a new mathematical model that combines large data sets to predict where different types of cells are located within the brain, based on their molecular identity.
Scientists at the Allen Institute for Brain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor-thin slices of mouse brain tissue. This approach yields brain maps that are collectively known as the Allen Mouse Brain Atlas. Each individual map shows where a single gene is expressed in the brain. When multiple maps are overlaid, patterns begin to emerge that show how different regions of the brain activate specific and often discrete complements of genes. These patterns are known as “co-expression” profiles.
Elsewhere, other research groups have taken a complementary approach, harvesting a single type of neuron from the brain and profiling all of the genes that are expressed by that cell. But this data lacks the spatial component of the atlas assembled by the Allen Brain Institute.
Mitra and postdoctoral fellow Pascal Grange, Ph.D., set out to integrate these two kinds of datasets. They devised a mathematical model that does just this. “Our model is simple,” says Mitra, “but it has predictive power. If the gene expression profile of a neuronal type is measured, then the model predicts where in the brain that type of neuron can be found.”
The significance of the new model, according to Grange, is that “it enables us to now have a biological understanding of the patterns, the co-expression profiles, seen in the Allen Gene Expression Atlas of the Mouse Brain.”
As scientists continue to generate larger datasets of gene activation for neurons, this model will allow them to draw an increasingly accurate map of their distribution in the brain. The eventual goal is to gain a better understanding of how signaling between different types of neurons controls memory and cognition.